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產品詳情
操作說明
注意事項
Product Information
|
Description |
VR1 rabbit polyclonal antibody |
|
Protein full name |
Transient receptor potential cation channel subfamily V member 1 |
|
Synonyms |
TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, VR1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse VR1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
95 kDa |
|
Observed MW. |
95 kDa |
|
Uniprot ID |
Q8NER1 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human |
1: 500-1: 1000 |
Hacat, T-47D, PC12 |
Background
TRPV1 is a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels. Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
Images
|
|
Western blot analysis of TRPV1 (GB111088) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室