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產品詳情
操作說明
注意事項
Product Information
|
Description |
IL-10 rabbit polyclonal |
|
Protein full name |
Interleukin-10 |
|
Synonyms |
IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10, Cytokine Synthesis Inhibitory Factor, Interleukin-10 precursor |
|
Immunogen |
Recombinant protein corresponding to Mouse IL-10 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Secreted |
|
Uniprot ID |
Applications
|
applications |
species |
dilution |
Positive tissue |
|
IHC |
Mouse, Rat |
1: 200-1: 1000 |
inflammatory lung, inflammatory liver, inflammatory spleen |
|
IF |
Mouse, Rat |
1: 200-1: 1000 |
inflammatory lung, inflammatory liver, inflammatory spleen |
Background
IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and Th1 T cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. IL-10 is linked to the myokines, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that physical exercise fosters an environment of anti-inflammatory cytokines.
Images
|
Immunohistochemistry analysis of paraffin-embedded mouse inflammatory lung using IL-10 (GB11534) at dilution of 1: 500 |
|
Immunohistochemistry analysis of paraffin-embedded rat inflammatory lung using IL-10 (GB11534) at dilution of 1: 500 |
|
Immunohistochemistry analysis of paraffin-embedded rat inflammatory spleen using IL-10 (GB11534) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室